Movement Disorders (revue)

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Interleukin‐1A (−889) genetic polymorphism increases the risk of multiple system atrophy

Identifieur interne : 004060 ( Main/Exploration ); précédent : 004059; suivant : 004061

Interleukin‐1A (−889) genetic polymorphism increases the risk of multiple system atrophy

Auteurs : Onofre Combarros [Espagne] ; Jon Infante [Espagne] ; Javier Llorca [Espagne] ; José Berciano [Espagne]

Source :

RBID : ISTEX:EA0122126C20CDFB90F8EF625D60F95ED90A83E1

Descripteurs français

English descriptors

Abstract

In a case‐control study using a clinically well‐defined group of 30 multiple system atrophy (MSA) patients and 110 control subjects, homozygosity for interleukin‐1A (IL‐1A) allele 2 (high secretor of proinflammatory cytokine) in the regulatory region (‐889) of the IL‐1A gene was associated with a fivefold increased risk for MSA. © 2003 Movement Disorder Society

Url:
DOI: 10.1002/mds.10540


Affiliations:


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Le document en format XML

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<term>Genotype</term>
<term>Homozygosity</term>
<term>Human</term>
<term>Humans</term>
<term>IL‐1A</term>
<term>Interleukin 1α</term>
<term>Interleukin-1 (genetics)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multiple System Atrophy (genetics)</term>
<term>Multiple System Atrophy (immunology)</term>
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<term>multiple system atrophy</term>
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<div type="abstract" xml:lang="en">In a case‐control study using a clinically well‐defined group of 30 multiple system atrophy (MSA) patients and 110 control subjects, homozygosity for interleukin‐1A (IL‐1A) allele 2 (high secretor of proinflammatory cytokine) in the regulatory region (‐889) of the IL‐1A gene was associated with a fivefold increased risk for MSA. © 2003 Movement Disorder Society</div>
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